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Metabolic Syndrome Screening

AI can help healthcare organizations (HCOs) identify individuals at-risk for developing Metabolic syndrome (MetS).

Problem

Metabolic syndrome (MetS) is a cluster of risk factors—central obesity, insulin resistance, dyslipidemia, and hypertension—that significantly increases the risk of cardiovascular disease and type 2 diabetes. It also often includes conditions such as excessive blood clotting and chronic low-grade inflammation, and has been linked to various cancers including breast, pancreatic, colon, and liver cancer (1)(2).

The prevalence of metabolic syndrome in Latin America ranges from 20% to 40% among adults, with higher rates observed in urban areas compared to rural regions. Factors such as lifestyle changes, urbanization, and dietary habits contribute to these high prevalence rates [3]. Despite its prevalence and serious implications, public awareness of MetS is low, with less than 15% of those at risk or with diabetes aware of the condition. Increasing awareness and early identification are crucial, as an additional 104 million people are at risk of developing MetS (6).

Why it matters

  • Approximately 80 million adults in the U.S. meet the criteria for MetS, representing a significant public health concern.
  • Healthcare costs for individuals with MetS are 60% higher than those without, with annual costs exceeding $220 billion [4,5].
  • Individuals with MetS are five times more likely to develop diabetes and have a threefold increased risk of cardiovascular disease.

Solution

AI-powered tools can enhance the accuracy and efficiency of screening processes by automating the analysis of clinical parameters such as blood pressure, glucose levels, and lipid profiles. This can help in early detection and timely intervention.

An AI model has been developed to predict the occurrence of MetS in individuals. It leverages physiological and lifestyle variables, offering healthcare providers a means to identify and support patients in high-risk categories for MetS with appropriate preventive measures.

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Datasources

The synthetic dataset was constructed by referencing extensive research and data from peer-reviewed studies and healthcare databases to closely replicate authentic clinical cases. Sources such as Steinberg et al. (1), NHLBI (2), O'Neill and O'Driscoll (3), Boudreau et al. (4), Yu et al. (5), and Lewis et al. (6), provided the necessary frameworks for model attributes, ensuring accurate MetS prediction.

Citations

  1. Steinberg, Gregory B., et al. “Novel Predictive Models for Metabolic Syndrome Risk: A 'Big Data' Analytic Approach.” The American Journal of Managed Care, vol. 20, no. 6, Jun. 24. pp:221-228. Accessed 20 Mar. 2021.
  2. NHLBI. Metabolic Syndrome | NHLBI, NIH. Nih.gov. Published December 28, 2020. Accessed March 24, 2021.
  3. O'Neill S, O'Driscoll L. Metabolic syndrome: a closer look at the growing epidemic and its associated pathologies. Obesity Reviews. 2014,16(1):1-12. doi:10.1111/0br.12229.
  4. Boudreau, D.M., et al. “Health Care Utilization and Costs by Metabolic Syndrome Risk Factors.” Metabolic Syndrome and Related Disorders, vol. 7, no. 4, Aug. 2009, pp. 305-314, doi:10.1089/met.2008.0070. Accessed 21 Mar. 2021.
  5. Yu, Yu, et al. “Air Pollution, Noise Exposure, and Metabolic Syndrome - a Cohort Study in Elderly Mexican-Americans in Sacramento Area.” Environment International, vol. 134, Jan. 2020, p. doi:10.1016/j.envint.2019.105269. Accessed 21 Mar. 2021.
  6. Lewis, S. J., et al. “Self-Reported Prevalence and Awareness of Metabolic Syndrome: Findings from SHIELD.” International Journal of Clinical Practice, vol. 62, no. 8, 29 Apr. 2008, pp. 1168-1176, doi:10.1111/j.1742-1241.2008.01770.x. Accessed 21 Mar. 2021.
  7. Choubey, U., Upadrasta, V.A., Kaur, I.P. et al. From prevention to management: exploring AI’s role in metabolic syndrome management: a comprehensive review. Egypt J Intern Med 36, 106 (2024). https://doi.org/10.1186/s43162-024-00373-x

Problem

Metabolic syndrome (MetS) is a cluster of risk factors—central obesity, insulin resistance, dyslipidemia, and hypertension—that significantly increases the risk of cardiovascular disease and type 2 diabetes. It also often includes conditions such as excessive blood clotting and chronic low-grade inflammation, and has been linked to various cancers including breast, pancreatic, colon, and liver cancer (1)(2).

The prevalence of metabolic syndrome in Latin America ranges from 20% to 40% among adults, with higher rates observed in urban areas compared to rural regions. Factors such as lifestyle changes, urbanization, and dietary habits contribute to these high prevalence rates [3]. Despite its prevalence and serious implications, public awareness of MetS is low, with less than 15% of those at risk or with diabetes aware of the condition. Increasing awareness and early identification are crucial, as an additional 104 million people are at risk of developing MetS (6).

Problem Size

  • Approximately 80 million adults in the U.S. meet the criteria for MetS, representing a significant public health concern.
  • Healthcare costs for individuals with MetS are 60% higher than those without, with annual costs exceeding $220 billion [4,5].
  • Individuals with MetS are five times more likely to develop diabetes and have a threefold increased risk of cardiovascular disease.

Solution

AI-powered tools can enhance the accuracy and efficiency of screening processes by automating the analysis of clinical parameters such as blood pressure, glucose levels, and lipid profiles. This can help in early detection and timely intervention.

An AI model has been developed to predict the occurrence of MetS in individuals. It leverages physiological and lifestyle variables, offering healthcare providers a means to identify and support patients in high-risk categories for MetS with appropriate preventive measures.

Opportunity Cost

AI optimizes the allocation of healthcare resources by identifying high-risk individuals and prioritizing them for preventive measures.

AI facilitates early detection of metabolic syndrome through predictive analytics, allowing for timely interventions that prevent the progression to more severe and costly health conditions such as cardiovascular diseases and diabetes.


Impact

AI is being integrated into the prevention, diagnosis, and treatment of metabolic syndrome, offering a transformative approach to managing this public health threat. AI can help overcome the limitations of traditional management methods by providing more precise and personalized healthcare solutions [7].


Data Sources

The synthetic dataset was constructed by referencing extensive research and data from peer-reviewed studies and healthcare databases to closely replicate authentic clinical cases. Sources such as Steinberg et al. (1), NHLBI (2), O'Neill and O'Driscoll (3), Boudreau et al. (4), Yu et al. (5), and Lewis et al. (6), provided the necessary frameworks for model attributes, ensuring accurate MetS prediction.


References

  1. Steinberg, Gregory B., et al. “Novel Predictive Models for Metabolic Syndrome Risk: A 'Big Data' Analytic Approach.” The American Journal of Managed Care, vol. 20, no. 6, Jun. 24. pp:221-228. Accessed 20 Mar. 2021.
  2. NHLBI. Metabolic Syndrome | NHLBI, NIH. Nih.gov. Published December 28, 2020. Accessed March 24, 2021.
  3. O'Neill S, O'Driscoll L. Metabolic syndrome: a closer look at the growing epidemic and its associated pathologies. Obesity Reviews. 2014,16(1):1-12. doi:10.1111/0br.12229.
  4. Boudreau, D.M., et al. “Health Care Utilization and Costs by Metabolic Syndrome Risk Factors.” Metabolic Syndrome and Related Disorders, vol. 7, no. 4, Aug. 2009, pp. 305-314, doi:10.1089/met.2008.0070. Accessed 21 Mar. 2021.
  5. Yu, Yu, et al. “Air Pollution, Noise Exposure, and Metabolic Syndrome - a Cohort Study in Elderly Mexican-Americans in Sacramento Area.” Environment International, vol. 134, Jan. 2020, p. doi:10.1016/j.envint.2019.105269. Accessed 21 Mar. 2021.
  6. Lewis, S. J., et al. “Self-Reported Prevalence and Awareness of Metabolic Syndrome: Findings from SHIELD.” International Journal of Clinical Practice, vol. 62, no. 8, 29 Apr. 2008, pp. 1168-1176, doi:10.1111/j.1742-1241.2008.01770.x. Accessed 21 Mar. 2021.
  7. Choubey, U., Upadrasta, V.A., Kaur, I.P. et al. From prevention to management: exploring AI’s role in metabolic syndrome management: a comprehensive review. Egypt J Intern Med 36, 106 (2024). https://doi.org/10.1186/s43162-024-00373-x

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